Atherosclerosis and Endothelium

Diet, the endothelium and atherosclerosis.

Dietary factors have been implicated in the difference in the risk of cardiovascular disease observed between populations. However, clinical trials and mechanistic studies of dietary modification are difficult to undertake, and the data set on dietary intervention for cardiovascular disease is now much smaller than that for pharmacological interventions. Moreover, the precise mechanism by which...

Endothelium, asymmetric dimethylarginine, and atherosclerosis in chronic kidney disease.

Shouldering the risk burden: infection, atherosclerosis, and the vascular endothelium.

Atherosclerosis, and the Vascular Endothelium To the Editors: The recent editorial by Drs Vita and Loscalzo1 was most informative and presents an overview of the relationships among infection, atherosclerosis, and consequent endothelial dysfunction. Their conclusion that “chronic infection may be added to the list of factors that induce endothelial dysfunction” is certainly warranted. Similarly...

Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit.

The effect of feeding a diet supplemented with lipids and containing 2% cholesterol on the endothelium-dependent relaxation of rabbit aorta to acetylcholine was assessed. The effect of feeding a standard rabbit diet after an initial period of 2% cholesterol feeding was assessed also. Age-matched male, New Zealand white rabbits were fed either a 2% cholesterol diet or a standard rabbit diet. The...

Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis.

Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism by which nanomedicines accumulate at targeted sites remains a topic of investigation, especially in the context of atherosclerotic disease. Models to accurately predict transvascular permeation of nanomedicines are needed to aid in design ...